Cascade reactions in total synthesis.

Organocatalytic cascade reactions as a new tool in total synthesis.

The total synthesis of natural products and biologically active compounds, such as pharmaceuticals and agrochemicals, has reached an extraordinary level of sophistication. We are, however, still far away from the 'ideal synthesis' and the state of the art is still frequently hampered by lengthy protecting-group strategies and costly purification procedures derived from the step-by-step protocol...

Synthesis of (±)-actinophyllic acid and analogs: applications of cascade reactions and diverted total synthesis.

Actinophyllic acid is a biologically active indole alkaloid with a unique structural framework that incorporates five contiguous stereocenters. A total synthesis of (±)-actinophyllic acid has been completed that proceeds in only 10 steps from readily available, known compounds and with the isolation of nine intermediates. The synthesis features a novel cascade of reactions of N-stabilized carbo...

Total synthesis of seco-lateriflorone

A convergent strategy toward the synthesis of lateriflorone (5) is described. Our approach is based on biosynthetic considerations and draws on a sequence of prenylation, oxygenation and Claisen reactions for the construction of chromenequinone 6, and a tandem Claisen/Diels–Alder reaction cascade for the synthesis of caged tricycle 7. Union of fragments 6 and 7 led to the synthesis of secolater...

Comparative Study of Two Various Percent of CO Injection Effect to Cascade Methanol Synthesis Reactor in the Presence of Long-term Catalyst Deactivation

A total synthesis of estrone based on a novel cascade of radical cyclizations.

Two conceptually different and novel radical-mediated cascade reactions leading to a total synthesis of the steroid (+/-)-estrone 1 and to a synthesis of 14-epiestrone 40 are described. Treatment of the iododienynone 23 with Bu(3)SnH/2,2'-azobis(isobutyronitrile) (AIBN) triggers a 13-endo-dig radical macrocyclization followed by two sequential radical transannulation reactions leading to the cr...